RNA Hydrogel Development Services
Despite its inherent chemical instability, RNA has been used to design and manufacture RNA hydrogels for biomedical applications. With years of experience in hydrogel development, Matexcel leverages its advanced technology platform and expertise to provide high-quality RNA hydrogel development services to our global customers. Our scientists are confident they can tailor the most reliable and cost-effective solutions to facilitate meaningful research for our customers.
Challenges of RNA Hydrogel
Ribonucleic acid (RNA) is a polymeric molecule that is essential in various biological processes of gene coding, decoding, regulation and expression. RNA can fold itself into complex tertiary structures such as kissing loops and pseudoknots. Although RNA plays an important role in biological processes due to its abundant structural motifs and functional diversity, the practical applications of single RNAs are limited by their inherent thermodynamic and chemical instability, difficulties in predicting structure and stability, and the small scale of production facilities. To achieve self-assembly of RNA into RNA hydrogels without any external support, RNA molecules need to be able to fold themselves into stable tertiary structures and can bind non-covalently to each other through unique intermolecular recognition sequences, thus spanning spatially into networks in 3D polymeric aqueous solutions. Currently, sequence-directed modular design can be used to generate RNA molecules with appropriate sequence motifs to construct RNA hydrogels with desired biological functions and mechanical properties. In addition, chemical modification of RNA monomers is required to make them resistant to ribonucleases for in vivo applications.
Fig. 1 Schematic representation of the RNA-triple-helix hydrogel for detection and therapy of TNBCs in vitro and in vivo and schematic diagram demonstrating programmable self-assembly of the RNA-triple-helix hydrogel. (Ding L., et al., 2020)
Applications of RNA Hydrogel in the Biomedical Field
Due to its excellent biocompatibility, biodegradability and programmability, RNA hydrogels have a wide range of promising applications in the biomedical field.
- Used as a drug delivery system to treat triple-negative breast cancer.
- Used to expand RNA-related research.
- Used as a cell-free protein expression platform to produce short peptides.
- Used for multiplex real-time pathogen detection.
Our Services
Matexcel leverages our advanced technology and extensive experience in hydrogel development to help our customers break through all the challenges in RNA hydrogel research and development. Our customized RNA hydrogel development services include, but are not limited to, the following.
- RNA Hydrogel Formulation Design Services: We provide customized RNA hydrogel formulation design services by designing RNA molecules with appropriate sequence motifs to construct RNA hydrogels with desired biological functions and mechanical properties for different application scenarios.
- RNA Hydrogel Modification Services: We can develop customized RNA hydrogel modification solutions by chemically modifying the RNA (e.g., replacing the 2′-OH group with 2′-fluoro or 2′-O-methyl groups) to enhance its stability in vivo.
- RNA Hydrogel Analysis and Characterization Services: We provide a full range of analysis and characterization services in the development of RNA hydrogels, as well as efficacy testing services for hydrogel samples.
Process of Our Service
Want to Learn More?
As a forward-thinking hydrogel development company, Matexcel has gained extensive experience in the completion of different projects, during which we have received wide recognition and praise from our customers. By combining cutting-edge technology with proprietary innovation, our scientists are dedicated to providing a full range of services related to RNA hydrogel development. If you are interested in our services, please fill out the online inquiry form and tell us more about your project.
Reference
- Ding L.; et al. A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer. J Mater Chem B. 2020, 8(16):3527-3533.