Poly(L-lysine)-Based Hydrogel Development Services
Poly(L-lysine)-based hydrogel is an emerging biomaterial with promising applications in tissue engineering, drug delivery, and other fields. Matexcel, as a preferred partner in hydrogel development, is committed to providing customized development services for poly(L-lysine)-based hydrogel to our global customers. Our team of experienced scientists and experts will provide expert technical support and advice at all stages of your project.
Introduction to Poly(L-lysine)-Based Hydrogel
As we all know, the inherent secondary structures of polypeptides, such as alpha helix, beta sheet and random coil, are determined by their amino acid sequences. And when the environmental pH and temperature change, the secondary structure of polypeptide will also exhibit conformational changes. For example, poly(L-lysine) (PLL), which has an amino group in the pendant chain, forms a random coil structure below pH 11, while when pH is higher than 11, the poly(L-lysine) chain changes to an inherent α-helix structure owing to neutral amino groups. Based on the property that poly(L-lysine) undergoes structural changes in response to changes in pH and ionic strength in aqueous solutions, pH-responsive poly(L-lysine) hydrogels can be prepared by a chemical cross-linking method. Nowadays, poly(L-lysine)-based hydrogel has been widely investigated for biomedical applications such as gene therapy vectors and tissue engineering scaffolds.
Fig. 1 Preparation of PLL hydrogel by crosslinking PLL with EGDE. (Matsumoto K., et al., 2015)
Applications of Poly(L-lysine)-Based Hydrogel in the Biomedical Field
Poly(L-lysine)-based hydrogel has good biocompatibility, PH responsiveness and modifiability, making it an emerging material with great potential for biomedical applications.
- Used in drug encapsulation and controlled delivery.
- Used as gene therapy vectors for biomedical applications.
- Used as a scaffold for tissue engineering.
- Used as a cell carrier to promote neural progenitor cell function for the treatment of nerve injury.
Our Services
Matexcel leverages our advanced technology and extensive experience in hydrogel development to help our customers break through all the challenges in poly(L-lysine)-based hydrogel research and development. Our customized poly(L-lysine)-based hydrogel development services include, but are not limited to, the following.
- Poly(L-lysine)-Based Hydrogel Formulation Design Services: We provide customized poly(L-lysine)-based hydrogel formulation design services to adjust the polymer concentration, cross-linking method, reaction temperature, pH, and other conditions of the hydrogel according to the different requirements of downstream applications for the mechanical and functional properties of hydrogels.
- Poly(L-lysine)-Based Hydrogel Modification Services: We can develop customized modification solutions to modify and optimize the original properties of poly(L-lysine)-based hydrogel, such as modifying its mechanical properties, biodegradability, pore size, and biochemical properties, depending on the requirements of various performance parameters for downstream applications.
- Poly(L-lysine)-Based Hydrogel Analysis and Characterization Services: We provide a full range of analysis and characterization services in the development of poly(L-lysine)-based hydrogels, as well as efficacy testing services for hydrogel samples.
Process of Our Service
Want to Learn More?
As a leading global provider of hydrogel R&D services, Matexcel has accumulated extensive experience in the completion of different projects, during which we have received wide recognition and praise from our customers. We have completed several challenging peptide-based hydrogel development services projects. We are proud to be able to provide our valued customers with high quality services to eliminate the difficulties in your projects. If you are interested in our services, please fill out the online inquiry form and tell us more about your project.
Reference
- Matsumoto K.; et al. Structural Transition of pH-Responsive Poly(L-Lysine) Hydrogel Prepared via Chemical Cross-linking. Chemistry Letters, 2015, 44(10):1284-1286.