Poly(2-hydroxyethyl methacrylate)-Based Hydrogel Development
Poly(2-hydroxyethyl methacrylate)(PHEMA)-Based Hydrogels are a promising material for a wide range of biomedical and pharmaceutical applications due to their biocompatibility, flexibility, and ease of customization. As a pioneer in hydrogel development, Matexcel is committed to developing customized poly(2-hydroxyethyl methacrylate)-based hydrogels for our global customers to meet their needs in a wide range of applications.
Advantages of Poly(2-hydroxyethyl methacrylate)-Based Hydrogel
Poly(2-hydroxyethyl methacrylate)-based hydrogel is a type of synthetic hydrogel that is widely used in biomedical applications due to its biocompatibility and unique physical properties. PHEMA-based hydrogels are formed by the polymerization of HEMA monomers in the presence of a crosslinking agent. The resulting polymer network is three-dimensional and highly hydrated, with a porous structure that allows for the diffusion of small molecules and nutrients.
One of the key advantages of PHEMA-based hydrogels is their biocompatibility and non-toxic, which means they are well tolerated by living tissue and do not elicit an immune response. They also have a high degree of mechanical stability, which allows them to maintain their shape and structure over extended periods of time. In addition, PHEMA-based hydrogels are also known for their optical clarity, which is important in applications such as contact lenses. Moreover, PHEMA-based hydrogels can be tailored to have specific properties, such as swelling capacity, mechanical strength, and degradation rate, by adjusting the amount of crosslinking agent and HEMA monomers used in their formation. This makes them a versatile material for a variety of biomedical applications.
Overall, PHEMA-based hydrogels are a versatile and useful material with a wide range of applications in biomedical research and engineering. Ongoing research is exploring ways to further improve the properties of PHEMA-based hydrogels and develop new applications for this exciting material.
Fig. 1 Modified hydrogels based on poly(2-hydroxyethyl methacrylate) (pHEMA) with higher surface wettability and mechanical properties. (Seo, E., et al., 2017)
Applications of Poly(2-hydroxyethyl methacrylate)-Based Hydrogel in Biomedicine
Poly(2-hydroxyethyl methacrylate) or PHEMA is a biocompatible and water-absorbent polymer that has found various applications, especially in the field of biomedical engineering. When PHEMA is cross-linked, it forms a hydrogel that can swell and absorb water, making it suitable for various applications such as drug delivery, tissue engineering, and contact lenses.
- Contact lenses: PHEMA-based hydrogels are widely used in the production of soft contact lenses due to their excellent oxygen permeability, high water content, and biocompatibility. The hydrogel is used to make contact lenses that are comfortable to wear and have a low risk of irritation or infection.
- Wound dressings: PHEMA-based hydrogels have been used as wound dressings due to their ability to maintain a moist environment and promote tissue regeneration. The hydrogel can absorb wound exudate and create a moist environment, which aids in the healing process.
- Drug delivery: PHEMA-based hydrogels have been used as drug delivery systems due to their ability to absorb and release drugs in a controlled manner. The hydrogel can be designed to release drugs over a period of time, providing a constant and controlled dosage.
- Tissue engineering: PHEMA-based hydrogels have been used in tissue engineering applications to create scaffolds for the growth and regeneration of tissue. The hydrogel can provide a 3D environment that supports cell growth and promotes tissue regeneration.
- Biosensors: PHEMA-based hydrogels have been used in the production of biosensors due to their ability to swell and absorb water. The hydrogel can be used to immobilize enzymes or other biomolecules, which can then be used to detect various analytes such as glucose or cholesterol.
- Implants: PHEMA-based hydrogels have been used in the production of implants such as artificial joints or other medical devices. The hydrogel can provide a biocompatible and durable material for implants that can withstand wear and tear.
Our Services
Matexcel leverages our advanced technology and extensive experience in hydrogel development to help our customers break through all the challenges in poly(2-hydroxyethyl methacrylate)-based hydrogel research and development. Our customized poly(2-hydroxyethyl methacrylate)-based hydrogel development services include, but are not limited to, the following.
- Poly(2-hydroxyethyl methacrylate)-Based Hydrogel Formulation Design Services
We offer customized poly(2-hydroxyethyl methacrylate)-based hydrogel formulation design services, where we take into account the specific requirements and specifications of your hydrogel application, such as required mechanical and swelling properties, biocompatibility, and drug release kinetics, to ensure that the PHEMA-based hydrogel formulation is tailored to your specific application. - Poly(2-hydroxyethyl methacrylate)-Based Hydrogel Modification Services
We offer modification services for poly(2-hydroxyethyl methacrylate)-based hydrogels, including the use of chemical modification, physical modification, and biological modification techniques to modify their properties or introduce new functionality. Some common modifications include cross-linking to increase its mechanical strength, surface modification to improve cell adhesion, and the incorporation of functional groups to achieve specific interactions with biomolecules. - Poly(2-hydroxyethyl methacrylate)-Based Hydrogel Analysis and Characterization Services
We provide a full range of analysis and characterization services in the development of poly(2-hydroxyethyl methacrylate)-based hydrogels, as well as efficacy testing services for hydrogel samples.
Process of Our Service
Want to Learn More?
With years of experience in hydrogel development, Matexcel is highly confident in providing multiple solutions for poly(2-hydroxyethyl methacrylate)-based hydrogel development. Currently, we have successfully established a comprehensive and robust technology platform to provide one-stop services from hydrogel raw material preparation and formulation customization to hydrogel analysis and characterization. If you are interested in our services, please fill out the online inquiry form and tell us more about your project.
Reference
- Seo, E., et al. Modified hydrogels based on poly(2-hydroxyethyl methacrylate) (pHEMA) with higher surface wettability and mechanical properties. Macromol. Res. 2017, 25:704–711.