Hyaluronic Acid-Based Hydrogel Development Services

Because of its inherent biodegradability, biocompatibility, and non-immunogenicity, hyaluronic acid is considered an excellent starting material for the construction of hydrogels with desirable stiffness, morphology, and bioactivity. Matexcel provides specialist services for producing hyaluronic acid-based hydrogels to facilitate their applications in various fields, including drug delivery, tissue engineering, cell therapy, regenerative medicine, and diagnostics. Our experienced scientists can build customized hyaluronic acid-based hydrogel development solutions to meet our customers' different downstream application needs.

Introduction to Hyaluronic Acid-Based Hydrogel

Hyaluronic acid (HA) is a natural, linear endogenous polysaccharide that plays an important physiological and biological role in the organism. Nowadays hyaluronic acid-based hydrogel is widely used in drug delivery, tissue engineering, cell therapy, regenerative medicine, and diagnostics. Therefore, the analysis and characterization of the hyaluronic acid-based hydrogel are essential to understand its biological function and develop potential medical applications. Due to the inability of hyaluronic acid to spontaneously form gels, several physical and chemical HA hydrogel design strategies have been developed to obtain hyaluronic acid-based hydrogels, such as click chemistry reactions, enzymatic cross-linking and disulfide cross-linking or supramolecular assembly methods. However, each of these strategies has its own advantages and disadvantages. For example, various chemical cross-linking techniques often require organic solvents or metal catalysts, which cause the formation of reaction by-products. Physically cross-linked hydrogels typically have lower mechanical and thermal stability. Therefore, it is usually necessary to select an appropriate synthesis method to adjust various physical and chemical parameters of the hydraulic acid-based hydrogel according to the required performance of specific applications during design.

Fig. 1 Preparation of the HA-PEG hydrogel. (Fu S, et al., 2017)

Applications of Hyaluronic Acid-Based Hydrogel

Hyaluronic acid-based hydrogel has many beneficial properties that make it an attractive polymeric material for a wide range of biomedical applications such as drug delivery, tissue engineering, regenerative medicine, cell therapy, and diagnostics.

• Use in tissue engineering applications, including bone tissue engineering, cartilage tissue engineering, skin tissue engineering, abdominal tissue engineering, vocal cord tissue engineering, and use as corneal defect fillers.
• Used in drug delivery, including targeted cancer therapy, Osteoarthritis Treatment, etc.
• Used in support of cell culture, including but not limited to the differentiation of induced pluripotent stem cells to neuronal production and preadipocyte culture.

Our Services

Matexcel leverages our expertise and extensive experience in hydrogel development to help our customers overcome all difficulties in the design and production of hyaluronic acid-based hydrogels. We are committed to working with our customers to advance the widespread application of hyaluronic acid-based hydrogels. Our customized hyaluronic acid-based hydrogel development services include but are not limited to the following:

• Hydrogel formulation design services: Based on customers' specific requirements for hyaluronic acid-based hydrogel mechanical properties and degradation rates, we vary the molecular weight of HA, the concentration of active HA precursors, and the degree of modification to prepare hydrogels with different hardnesses, pore sizes, and degradation rates, while maintaining their inherent biological functions. We specialize in providing professional and efficient customized hyaluronic acid-based hydrogel solutions to our customers.
• Hydrogel modification services: Depending on the physicochemical properties of the hyaluronic acid-based hydrogels, we select appropriate methods such as chemical grafting and physical blending to modify and optimize the original properties of the hydrogel to give it new excellent properties, such as excellent biocompatibility, degradability, easily adjustable physicochemical properties and structure.
• Hydrogel analysis and characterization services: We provide a full range of analysis and characterization services in the development of hyaluronic acid-based hydrogels, as well as efficacy testing services for hyaluronic acid-based hydrogel samples.

Process of Our Service

Want to Learn More?

Matexcel is committed to helping our customers overcome all difficulties in the hyaluronic acid-based hydrogel research and development process. If you are interested in our services, please fill out the online inquiry form and tell us more about your project.

References

1. Xu X; et al. Hyaluronic acid-based hydrogels: From a natural polysaccharide to complex networks. Soft Matter. 2012, 8(12):3280-3294.
2. Trombino S; et al. Strategies for hyaluronic acid-based hydrogel design in drug delivery. Pharmaceutics. 2019, 11(8):407.