Collagen-Based Hydrogel Development Services

Collagen is a major structural protein found in vertebrates and is highly prized for its excellent biocompatibility, low immunogenicity, versatility and its excellent biodegradation properties. Matexcel, as a hydrogel development expert, is committed to helping our customers overcome all the difficulties of collagen-based hydrogels in a wide range of applications in biomedical, pharmaceutical, and other fields. We are looking forward to collaborating with our customers to explore the potential of collagen-based hydrogel for more applications.

Introduction to Collagen-Based Hydrogel

Collagen is the most abundant protein in animals with a triple helix structure, biodegradability, biocompatibility, biomimetic and hemostatic properties. Collagen-based biomaterials, such as collagen-based hydrogel, are widely used in pharmaceutical, biomedical, cosmetic, and food research because of their easy availability, low cost, and programmable properties. Although collagen has excellent thermal, mechanical, elastic, and enzymatic stability in vivo, these properties are greatly reduced when it is extracted and used, so improvements to collagen are needed to make it better for use. In order to improve or obtain the required properties for a specific application, different improvement methods such as covalent binding, graft polymerization, cross-linking (physical, chemical, and enzymatic), and blending methods can be used to meet the performance requirements of collagen-based hydrogel for a particular application. In recent years, collagen-based hydrogel has made great progress in several fields and has laid an important foundation for future development. In addition, more improvement technologies need to be explored to develop the potential of collagen-based hydrogel for more applications.

Fig. 1 Collagen type I is gelled using various methods to form a hydrogel system. (Sarrigiannidis SO, et al., 2021)

Applications of Collagen-Based Hydrogel in the Biomedical Field

The beneficial properties of collagen-based hydrogel, such as low cost, versatility, low immunogenicity, biocompatibility, and similarity to natural extracellular matrix (ECM), make it suitable for various applications in the biomedical field.

• Used in drug delivery.
• Used in the repair of cardiovascular diseases, neurological diseases, bone defects, and tendon injuries.
• Used in corneal stromal regeneration.
• Used in wound healing.
• Used for 3D cell culture.
• Used to promote neural stem cell proliferation and differentiation.
• Used to deliver mesenchymal stem cell for cartilage regeneration.

Our Services

Matexcel leverages our advanced technology and extensive experience in hydrogel development to help our customers break through all the challenges in collagen-based hydrogel research and development. Our customized collagen-based hydrogel development services include but are not limited to, the following.

• Collagen-Based Hydrogel Formulation Design Services: We customize different collagen-based hydrogel development solutions to precisely meet our customer's requirements for a variety of exciting and high-growth applications by employing different methods such as covalent bonding, graft polymerization, cross-linking, and blending methods to modify the functional properties of hydrogels such as permeability, aqueous swelling, diffusivity, and degradability.
• Collagen-Based Hydrogel Modification Services: We can develop tailor-made modification solutions to modify and optimize the original properties of the collagen-based hydrogel, such as its mechanical properties in terms of strength, elasticity, or compliance, depending on the performance parameters required by the downstream application.
• Collagen-Based Hydrogel Analysis and Characterization Services: We provide a full range of analysis and characterization services in the development of collagen-based hydrogels, as well as efficacy testing services for collagen-based hydrogel samples.

Process of Our Service

Want to Learn More?

With extensive and trusted experience and renowned experts, Matexcel is confident to provide our customers with highly comprehensive and efficient collagen-based hydrogel development services. If you are interested in our services, please fill out the online inquiry form and tell us more about your project.

References

1. Sarrigiannidis SO; et al. A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities. Mater Today Bio. 2021, 10:100098.
2. Geanaliu-Nicolae RE; Andronescu E. Blended Natural Support Materials-Collagen Based Hydrogels Used in Biomedicine. Materials (Basel). 2020, 13(24):5641.