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Product Infomation
Catalog Number NAT-0003
Product Name Collagen from human placenta (Type IV)
Description Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. During development, Collagen IV is ubiquitously distributed in BMs. During the maturation process, this network gets partially replaced in a remarkably tissue specific manner, defining BM structure and function. Collagen IV has been shown to bind to platelets, hepatocytes, keratinocytes, endothelial, mesangial, pancreatic cells and some tumor cells. Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain. Mutations in COL4A5 are associated with Alport syndrome.
Morphology & Appearance powder
Purity An SDS polyacrylamide gel electrophoresis test run under reducing conditions consistent with basement membrane Collagen yields three major bands.
Source human placenta
Storage 20°C
Application Type IV Collagen has been found to play a key role in angiogenesis, neurological diseases and metastasis. Collagen from human placenta has been used to assess the bioelectric effects of quinine on airway epithelial cells, to study the selective toxicity of engineered lentvirus lytic peptides and in a particle aggregation assay for the rapid detection of fibronectin, fibrinogen and Collagen receptors on Staphylococcus aureus. It has also been used in a magnesium-dependent, Collagen-binding assay during characterization of human lung tumor-associated antigens.
Usage This powder can be reconstituted in sterile .5 M acetic acid, PBS or water at 1 mg/mL. A PBS solution will be stable for at least one year at -20°C.
Components All Collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type IV Collagen occurs only in the basement membranes and contains up to six genetically distinct a-chains.
Warning This product should be stored desiccated at -20°C, and will retain activity in these conditions for 3 years.
solubility 0.5 M acetic acid: 1 mg/mL, clear to very slightly hazy
impurities HIV, hepatitis B and hepatitis C, none detected
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